Acetyl-CoA Carboxylase
ACC, Acetyl Coenzyme A Carboxylase
Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.
In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).
All Product Categories
-
Acetyl-CoA Carboxylase Inhibitors
(67)
View all products
-
Acetyl-CoA Carboxylase Agonist
(1)
View all products
-
Acetyl-CoA Carboxylase Activators
(11)
View all products
-
Acetyl-CoA Carboxylase Modulators
(3)
View all products
-
Acetyl-CoA Carboxylase Degrader
(1)
View all products
-
Acetyl-CoA Carboxylase Ligand
(1)
View all products
-
Acetyl-CoA Carboxylase Related Products (92)
Related Products (92)
-
Antibodies (5)
-
Fluazifop-P-butyl
0 ImagesFluazifop-P-butyl is an orally active herbicide and ACCase inhibitor. Fluazifop-P-butyl blocks the formation of malonyl-CoA, disrupts lipid synthesis in sensitive plants, and exhibits concentration-dependent phytotoxicity to non-target maize seedlings. Fluazifop-P-butyl induces oxidative stress in male Wistar rats, impairs their liver and kidney functions, and disrupts testicular function.
-
Alisol A 24-acetate
0 ImagesSynonyms: Alisol A 24-monoacetate; Alisol A monoacetateAlisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis.
-
Isomangiferin
0 ImagesIsomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
-
Sethoxydim
0 ImagesCat. No.: HY-135753CAS No.: 74051-80-2Synonyms: BAS 9052Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity.
-
hACC2-IN-1
0 ImageshACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research.
-
Acetyl-CoA Carboxylase-IN-1
0 ImagesAcetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity.
-
9-Oxononanoic acid
0 ImagesSynonyms: 9-ONA9-Oxononanoic acid (9-ONA) is an orally active acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2 activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis.
-
Firsocostat (S enantiomer)
0 ImagesSynonyms: ND-630 (S enantiomer); GS-0976 (S enantiomer); NDI-010976 (S enantiomer)Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase (ACC) inhibitor.
-
Selovoxolone
0 ImagesSynonyms: CKBASelovoxolone (CKBA), a derivative of AKBA (HY-N0892) is an inhibitor of acetyl-CoA carboxylase 1 (ACC1), with an IC50 of 5.02 μM. Selovoxolone inhibits the differentiation of Th17 cells and has IC50 values of 3.28 μM for mouse cells and 3.61 μM for human cells. Selovoxolone ointment significantly alleviates psoriasis-like inflammation in mice. Selovoxolone can be used for the study of psoriasis.
-
Fenoxaprop-P-ethyl
0 ImagesFenoxaprop-P-ethyl is an acetyl-CoA carboxylase (ACC) inhibitor and post-emergence herbicide. Fenoxaprop-P-ethyl inhibits the conversion of acetyl-CoA to malonyl-CoA, reduces malonyl-CoA synthesis and disrupts fatty acid synthesis. Fenoxaprop-P-ethyl disrupts lipid homeostasis through cascaded inhibition of lipid metabolism, decreases total lipid content, downregulates fatty acid elongase genes and inhibits their activity. Fenoxaprop-P-ethyl disrupts fatty acid synthesis in rice seedlings and controls annual monocotyledonous weeds in wheat, durum wheat, rye, triticale and barley fields.
-
CAD031
0 ImagesCAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice.
-
Propaquizafop
0 ImagesPropaquizafop is a phenoxyisopropionic acid herbicide and an acetyl-coA carboxylase inhibitor.
-
Clethodim (Standard)
0 ImagesCat. No.: HY-119896RCAS No.: 99129-21-2Clethodim Standard is the analytical standard of Clethodim (HY-119896). This product is intended for research and analytical applications. Clethodim is a potent acetyl-CoA A carboxylase (ACCase) inhibitor and herbicide. Clethodim inhibits ACCase in plants, thereby blocking fatty acid biosynthesis required for cell membrane and secondary metabolite production. Clethodim exhibits developmental toxicity and neurotoxicity in zebrafish embryos and larvae. Clethodim is used in studies on agricultural herbicides and developmental toxicity.
-
Kudinoside D
0 ImagesKudinoside D is a triterpenoid saponin. Kudinoside D is isolated from the leaves of Ilex kudingcha. Kudinoside D enhances the phosphorylation levels of AMPK and its downstream molecule ACC, and inhibits the expression of PPARγ, C/EBPα, SREBP-1c as well as the target genes of adipogenic transcription factors. Kudinoside D inhibits the activity of ANO1. Kudinoside D possesses hypolipidemic activity. Kudinoside D can be used in obesity-related research.
-
XZA-1
0 ImagesXZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase (HADH) activator. XZA-1 increases the intracellular level of acetoacetyl-CoA, which in turn induces acetoacetylation modification of Chromobox Protein Homolog 4 (CBX4) at lysine 106 (K106). XZA-1 exhibits antitumor effects in a xenograft model of human hepatocellular carcinoma SMMC7721 cells overexpressing CBX4. XZA-1 can be used for the study of hepatocellular carcinoma.
-
Moiramide B
0 ImagesMoiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of 6 nM. Moiramide B has antibacterial activity.
-
Quizalofop
0 ImagesSynonyms: XylafopQuizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production.
-
Tepraloxydim
0 ImagesTepraloxydim is an acetyl-CoA carboxylase inhibitor with weed control activity.
